2005年3月在美國奧蘭多分子影像學(xué)會年會上，來自七所大學(xué)和公司的科學(xué)家在報告中，報道了使用兩種新型造影劑用于微型CT以及CT成像的結(jié)果以及摘要。

Alerion生物醫(yī)學(xué)集團(tuán)(San Diego, CA, USA)總裁兼首席執(zhí)行官Michael Beeuwsaert評論說：“Fenestra產(chǎn)品線一直激勵那些工作在腫瘤學(xué)、血管疾病、肝膽疾病以及其它疾病領(lǐng)域的研究人員。Fenestra極大地提高了體內(nèi)成像的價值，不僅提高了成像質(zhì)量，而且更重要的是，允許研究人員開展各種研究，用以解答在這項技術(shù)投入使用之前無法解決的問題。”

Fenestra與微型CT和傳統(tǒng)CT成像系統(tǒng)都能夠兼容， 是由Alerion公司研制開發(fā)的，允許研究人員能夠在各種各樣的動物模型之中觀察解剖與功能的變化。而且，它能夠在相同動物之中重復(fù)給藥，從而無需處死動物以及評估多個動物模型。Fenestra技術(shù)是以包含在油水脂質(zhì)乳劑的親脂核心中的碘化甘油三酯為基礎(chǔ)的，這與體內(nèi)能夠攜帶脂質(zhì)的天然生成的乳糜微滴殘余物相似。依賴這種乳劑制劑的特征，這種藥物提供了解剖結(jié)構(gòu)的長期觀察能力，這種特征在使用微型CT掃描儀的時候極其有用，可以產(chǎn)生較長的數(shù)據(jù)獲取時間以及穩(wěn)定的對比增強輪廓。
 
CT Contrast Agent Shows Potential
 
Findings using two new contrast agents for micro-computed tomography (CT) and CT imaging were features in presentations and abstracts by scientists from seven universities and companies during the March 2005 annual meeting of the Academy of Molecular Imaging in Orlando (FL, USA).

“The Fenestra product line continues to excite researchers working in the areas of oncology, vascular disease, hepatobiliary disease, and many others. Fenestra greatly enhances the value of in vivo imaging by not only improving the quality of the images, but more importantly, enabling researchers to perform studies designed to answer questions they didn’t even know they could ask before this technology was available,” remarked Michael Beeuwsaert, president and CEO of Alerion Biomedical, Inc. (San Diego, CA, USA).

Compatible with both micro-CT and conventional CT imaging systems, Fenestra, developed by Alerion, allows investigators to view anatomy and function in a wide variety of animal models. Furthermore, it can be administered repeatedly to the same animal, eliminating the need to sacrifice and assay multiple animal models. The underlying technology of Fenestra is based on iodinated triglycerides contained in the lipophilic cores of oil-in-water lipid emulsions similar to the naturally-occurring chylomicron remnants that carry lipids within the body. Depending on the characteristics of the emulsion formulation, this agent provides long-lasting visualization of anatomic features, a feature particularly useful for use with micro-CT scanners that benefit from longer data acquisition times with stable contrast enhancement profiles.